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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 346435생성일: 2026년 10월 25일

Phosphate → (S)-alpha-(Trifluoromethyl)benzyl alcohol

https://huagongshe.com/reaction/346435

반응식

참여 물질

역할이름HCID투입량
반응물PhosphateHCID 1061—
반응물IsopropanolHCID 3776—
반응물2,2,2-TrifluoroacetophenoneHCID 9905—
용매Ethyl AcetateHCID 8857—
생성물(S)-alpha-(Trifluoromethyl)benzyl alcoholHCID 95556—

반응 조건

온도30 °C

반응 단계

To 0.02 g of the aforementioned wet bodies was added 500 μl of 50 mM phosphate buffer (pH 7.0) containing 1% 2,2,2-trifluoroacetophenone and 5% 2-propanol, followed by stirring at 30° C. for 18 hours. Then, after adding 500 μl of ethyl acetate to the reaction mixture, the mixture was subjected to centrifugal separation to obtain the organic phase. The organic phase was subjected to an analysis of the content by way of gas chromatography under the following condition. 2,2,2-Trifluoro-1-phenylethanol was produced at a ratio of 49.4% based on the amount of 2,2,2-trifluoroacetophenone used in the reaction. Furthermore, optical purity of 2,2,2-trifluoro-1-phenylethanol in the organic phase was measured under the following condition. The (S)-form of 99% e.e. was demonstrated.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07172894B2
출처 데이터셋uspto-grants-2007_02
ORD IDord-3b169d156aa444c09b848c7a39e4a6d4
출처 메모uspto-grants-2007_02