Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Ethylpropanedioyl dichloride → 3-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-3-oxo-propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Ethylpropanedioyl dichloride | HCID 10920924 | — |
| 반응물 | 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride | HCID 21080184 | — |
| 반응물 | 3-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-3-oxo-propionic acid ethyl ester | HCID 69290734 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 3-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-3-oxo-propionamide | HCID 11772683 | 70% |
반응 단계
3-[7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl]-3-oxo-propionic acid ethyl ester: The title compound was prepared in analogy to Example 1d) from 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride [Example 1c)] and ethyl malonic acid chloride with triethylamine as the base. Yield: 70% of theory as a colourless oil; MS: m/e=386 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07173023B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-0cc9c9d9b5fb4a71ae071e7b3c235fb3 |
| 출처 메모 | uspto-grants-2007_02 |