Methyl chloroformate → 7-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic Acid Methyl Ester

HRID 346451노트

반응식

HRID 346451 반응식
Cl.[F:2][C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[CH2:6][O:7][C:8]1[CH:18]=[CH:17][C:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:10]=2[CH:9]=1.Cl[C:23]([O:25][CH3:26])=[O:24]>C(N(CC)CC)C>[CH3:26][O:25][C:23]([N:14]1[CH2:15][CH2:16][C:10]2[CH:9]=[C:8]([O:7][CH2:6][C:5]3[CH:19]=[CH:20][CH:21]=[C:3]([F:2])[CH:4]=3)[CH:18]=[CH:17][C:11]=2[CH2:12][CH2:13]1)=[O:24]

참가 물질

4

반응물 2

HCID 6586Methyl chloroformateHCID 210801847-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride

생성물 1

HCID 111865177-(3-Fluoro-benzyloxy)-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic Acid Methyl Ester수율 95%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

The title compound was prepared in analogy to Example 1d) from 7-(3-fluoro-benzyloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride [Example 1c)] and methyl chloroformate with triethylamine as the base. Yield: 95% of theory as a colourless oil; MS: m/e=330 (M+H)+.

출처 및 근거

ORD 기록
ord-17a7465a1e4348db8c123b7186989223
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07173023B2

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