Propynal → 5(6H)-Quinolinone, 7,8-dihydro-

HRID 34648

반응식

HRID 34648 반응식
[CH:1](=O)[C:2]#[CH:3].[NH2:5][C:6]1[CH2:11][CH2:10][CH2:9][C:8](=[O:12])[CH:7]=1>CN(C)C=O>[N:5]1[C:6]2[CH2:11][CH2:10][CH2:9][C:8](=[O:12])[C:7]=2[CH:3]=[CH:2][CH:1]=1

참가 물질

4

반응물 2

HCID 12222PropynalHCID 788923-Aminocyclohex-2-en-1-one

생성물 1

HCID 30168115(6H)-Quinolinone, 7,8-dihydro-수율 54.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The procedure of Rimek and Zymalkowski (Arch. Pharm. 1961, 294, 759-765) was followed. Over a period of 1 hour, 40.9 g (0.757 mol) of freshly-distilled propiolaldehyde was added dropwise to a solution of 42.1 g (0.379 mol) of 3-amino-2-cyclohexenone in 1.5 1 of N,N-dimethylformamide (DMF). The solution was stirred at room temperature for 12 hours. The DMF was evaporated at reduced pressure. Vacuum distillation (bp 60°-65° C. at 0.025-0.050 mmHg) of the resultant black tars gave 30.2 g (54.2%) of 7,8-dihydro-5(6H)-quinolinone as a colorless liquid.

후처리

  1. customThe DMF was evaporated at reduced pressure
  2. distillationVacuum distillation (bp 60°-65° C. at 0.025-0.050 mmHg) of the resultant black tars

출처 및 근거

ORD 기록
ord-d095c268899d483fbe6ef5a5fd78e336
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762843

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