Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 6-Bromo-2-pyridin-2-ylquinoline-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 5-Bromoisatin | HCID 6889 | — |
| 반응물 | 2-Acetylpyridine | HCID 14286 | — |
| 용매 | Potassium Hydroxide | HCID 14797 | — |
| 생성물 | 6-Bromo-2-pyridin-2-ylquinoline-4-carboxylic acid | HCID 759123 | — |
반응 단계
To a suspension of 5-bromo isatin (5 g, 20.5 mmol) and 2-acetylpyridine (2.5 g, 20.5 mmol) in aqueous KOH (1.2 g, 33%) was added EtOH until a solution formed. The mixture was refluxed over night. The reaction mixture was neutralized with HOAc (50%) and filtered. The solid was resuspended in EtOH and filtered to give the title compound (5.5 g). LC: 1.66 and MH+: 329.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07173042B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-66ea86aa294340e2ad098a4c0c526363 |
| 출처 메모 | uspto-grants-2007_02 |