참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Bromopropionic acid | HCID 11729 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | HCID 178470113 | HCID 178470113 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Carboxy-2-carboxyethylthio-1,3-thiazole | HCID 14415208 | — |
반응 단계
6.9 g of bromopropionic acid were dissolved in 100 ml of water, and the pH was adjusted to 7 with 1N NaOH. This solution was added dropwise to a suspension of 7.5 g of 4-ethoxycarbonyl-2-mercapto-1,3-thiazole in 75 ml of H2O. The pH was adjusted to 8-10 with 2N NaOH, and the mixture was stirred at room temperature for 4 h and at 60° C. for 2 h. The pH was maintained between 8 and 10. While cooling in ice, the mixture was acidified to pH 1 with 2N HCl, and the product was filtered off.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04762848 |
|---|
| 출처 데이터셋 | uspto-grants-1988_08 |
|---|
| ORD ID | ord-437e342210694b3fa36739d83cf07047 |
|---|
| 출처 메모 | uspto-grants-1988_08 |
|---|
