Tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate → HCID 15093271, 화합물

HRID 34672노트

반응식

HRID 34672 반응식
[C:1]([CH2:5][CH2:6][S:7][C:8]1[S:12][CH:11]=[N:10][C:9]=1[C:13]([O:15]C(C)(C)C)=[O:14])([O:3][CH3:4])=[O:2]>FC(F)(F)C(O)=O>[C:1]([CH2:5][CH2:6][S:7][C:8]1[S:12][CH:11]=[N:10][C:9]=1[C:13]([OH:15])=[O:14])([O:3][CH3:4])=[O:2]

참가 물질

3

반응물 1

HCID 15093267Tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate

생성물 1

HCID 15093271HCID 15093271, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

7.8 g of tert.-butyl 5-(2-carbomethoxyethylthio)-1,3-thiazol-4-ylcarboxylate are stirred in a mixture of 100 ml of trifluoroacetic acid and 100 ml of methylene ohloride at room temperature for 30 min. The solvent is removed in vacuo, and the residue is extracted by stirring with 100 ml of ether/petroleum ether (50°-70° C.) 1/1. After filtration and drying, 6.2 g of melting point 112°-116° C. are obtained, melting point 120°-121° C. after recrystallization from ethyl acetate.

후처리

  1. customThe solvent is removed in vacuo
  2. extractionthe residue is extracted
  3. filtrationAfter filtration
  4. customdrying
  5. custom6.2 g of melting point 112°-116° C. are obtained
  6. custommelting point 120°-121° C. after recrystallization from ethyl acetate

출처 및 근거

ORD 기록
ord-e56279be3e36461cb3c5171b1f57e0d3
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762848

반응 노트

불러오는 중…