Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 346741생성일: 2026년 10월 25일
3-Fluorobenzenesulfonamide → N-(4-(1,4-diazepan-1-yl)-2-{[(3-fluorophenyl)sulfonyl]amino}phenyl)-3-fluorobenzenesulfonamide hydrochloride
https://huagongshe.com/reaction/346741
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Fluorobenzenesulfonamide | HCID 150924 | — |
| 반응물 | 3-Fluorobenzenesulfonyl Chloride | HCID 2734258 | — |
| 반응물 | Ether hydrochloride | HCID 10953452 | — |
| 반응물 | Tert-butyl 4-(3,4-diaminophenyl)-1,4-diazepane-1-carboxylate | HCID 22272464 | — |
| 반응물 | N-{2-amino-4-[4-t-butyloxycarbonyl-homopiperazin-1-yl-]phenyl}3-fluorobenzenesulfonamide | HCID 22272531 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N-(4-(1,4-diazepan-1-yl)-2-{[(3-fluorophenyl)sulfonyl]amino}phenyl)-3-fluorobenzenesulfonamide hydrochloride | HCID 10209725 | — |
반응 단계
The compound was prepared from 2-amino-5-(4-t-butyloxycarbonyl-1-homopiperazinyl)aniline and 3-flourobenzenesulfonyl chloride. Purification by column chromatography (CH2Cl2/MeOH/heptane, 4:1:15) gave a mixture of N-{2-amino-4-[4-t-butyloxycarbonyl-homopiperazin-1-yl-]phenyl}3fluorobenzenesulfonamide and N-{4-[4-t-butyloxycarbonyl] homopiperazinyl)-2-[(3-flourophenylsulfonyl)amino]phenyl}-3-fluorobenzenesulfonamide (0.180 g, 73%). Boc-deprotection was achieved by dissolving the mixture in small amount of MeOH and adding HCl/ether. The mixture was let at r.t. for 0.5 h. Purification by preparative HPLC gave N-(4-(1,4-diazepan-1-yl)-2-{[(3-fluorophenyl)sulfonyl]amino}phenyl)-3-fluorobenzenesulfonamide hydrochloride Anal. (C23H27ClN4O4S2) C, H, N, S.; M+524.4 Calcd 522.12.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07173035B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_02 |
|---|
| ORD ID | ord-3a95fe92913446f8b4b452cab16de588 |
|---|
| 출처 메모 | uspto-grants-2007_02 |
|---|
