Nitroethane → 1-Hydroxy-2-methyl-3-oxidobenzimidazol-3-ium
반응식
[N+:1]1([O-:10])[O:5][N:4]=[C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=12.[N+]([CH2:14][CH3:15])([O-])=O.C(NCC)C>O1CCCC1>[CH3:14][C:15]1[N:4]([OH:5])[C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[N+:1]=1[O-:10]참가 물질
5
실험 절차
In the typical procedure, 0.1 mole of benzofurazan 1-oxide and 0.12 mole of nitroethane is dissolved at 100 ml. of tetrahydrofuran. To this mixture there is added at room temperature, 0.12 mole of diethylamine over a period of 0.5 hour. An instantaneous exothermic reaction is observed (40° C.) and within one hour, the product crystallizes from the solution. The solution is allowed to stand overnight at room temperature and filtered to yield 9.6 grams of 2-methyl-1-hydroxy-1-H-benzimidazole 3-oxide (Table I, Example 2). The product can be rectystallized from methanol.
후처리
- additionTo this mixture there is added at room temperature
- customAn instantaneous exothermic reaction
- custom(40° C.)
- customthe product crystallizes from the solution
- waitto stand overnight at room temperature
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-30e2e597742e44bcb9f8d17534a43186
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04762870
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