4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride → 4-(5-fluoro-1H-indol-3-yl)butanoic acid (4-dimethylamino-4-phenylcyclohexylmethyl)amide

HRID 346802노트

반응식

HRID 346802 반응식
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][C:6]([N:15]([CH3:17])[CH3:16])([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.[Cl-].COC1N=C(OC)N=C([N+]2(C)CCOCC2)N=1.[F:36][C:37]1[CH:38]=[C:39]2[C:43](=[CH:44][CH:45]=1)[NH:42][CH:41]=[C:40]2[CH2:46][CH2:47][CH2:48][C:49](O)=[O:50]>CO>[CH3:16][N:15]([CH3:17])[C:6]1([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:5][CH2:4][CH:3]([CH2:2][NH:1][C:49](=[O:50])[CH2:48][CH2:47][CH2:46][C:40]2[C:39]3[C:43](=[CH:44][CH:45]=[C:37]([F:36])[CH:38]=3)[NH:42][CH:41]=2)[CH2:8][CH2:7]1

참가 물질

5

반응물 3

HCID 27340594-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chlorideHCID 150472684-(5-Fluoro-1H-indol-3-yl)butanoic acidHCID 21082146(4-Aminomethyl-1-phenylcyclohexyl)dimethylamine

생성물 1

HCID 102542024-(5-fluoro-1H-indol-3-yl)butanoic acid (4-dimethylamino-4-phenylcyclohexylmethyl)amide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of the diastereoisomers of (4-aminomethyl-1-phenylcyclohexyl)dimethylamine (465 mg, 2 mmol.) and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (830 mg, 3 mmol.) was added to a solution of 4-(5-fluoro-1H-indol-3-yl)butanoic acid (443 mg, 2 mmol.) in abs. methanol (10 ml), and stirring was carried out for 24 h at RT. For working up, the mixture was concentrated, water (5 ml) was added to the solid residue, and the pH was adjusted to 11 with 2M NaOH. Extraction was carried out with EE (5×10 ml), and the combined extracts were washed with 1M NaOH (2×3 ml), dried, filtered and concentrated. The residue was a diastereoisomeric mixture of the bases of the target product, which was separated by flash chromatography on silica gel (50 g) and purified (eluant: 700 ml of ethanol/EE 1:1). 260 mg (0.59 mmol.) of the non-polar diastereoisomer of 4-(5-fluoro-1H-indol-3-yl)butanoic acid (4-dimethylamino-4-phenylcyclohexylmethyl)amide were obtained in the form of a light-yellow viscous oil; the oil was dissolved in 2-butanone (7 ml), and chlorotrimethylsilane (113 μl, 0.89 mmol.) was added thereto. There immediately formed a white precipitate, which was deposited in a tacky manner on the wall of the flask. The solvent was reduced to about 3 ml in vacuo and, after addition of ether (3 ml), vigorous stirring was carried out at RT for 1 h. The solid that formed was filtered off with suction, washed with ether (3×1.5 ml) and dried in vacuo. The hydrochloride of the non-polar diastereoisomer of 4-(5-fluoro-1H-indol-3-yl)butanoic acid (4-dimethylamino-4-phenylcyclohexylmethyl)amide was thus obtained in the form of a hygroscopic solid in a yield of 272 mg.

후처리

  1. concentrationthe mixture was concentrated
  2. additionwater (5 ml) was added to the solid residue
  3. extractionExtraction
  4. washthe combined extracts were washed with 1M NaOH (2×3 ml)
  5. customdried
  6. filtrationfiltered
  7. concentrationconcentrated
  8. additiona diastereoisomeric mixture of the bases of the target product, which
  9. customwas separated by flash chromatography on silica gel (50 g)
  10. custompurified (eluant: 700 ml of ethanol/EE 1:1)

출처 및 근거

ORD 기록
ord-6e631d74638c40a0857f7203a6c74b2c
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07173045B2

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