Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 1-benzyl-2-methyl-2,3-dihydro-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Methylindoline | HCID 23305 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-benzyl-2-methyl-2,3-dihydro-1H-indole | HCID 10513589 | 101.5% |
반응 단계
To a solution of 1 g (7.5 mmol) of 2-methyl-2,3-dihydro-1H-indole in anhydrous DMF were added 1.03 g (7.5 mmol) of K2CO3 and then dropwise 0.97 mL (8.0 mmol) of benzylbromide. The mixture was stirred at RT for 3hrs and then distributed between Et2O and a saturated aqueous solution of NH4Cl. The combined organic phases were dried over Na2SO4 and evaporated to yield 1.7 g (quantitative) of crude 1-benzyl-2-methyl-2,3-dihydro-1H-indole, light blue oil, MS: 224 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07173048B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-2a2f6613161d4ab09e81152c621626b0 |
| 출처 메모 | uspto-grants-2007_02 |