Ethanol → 4-(4-Pentenoxy)-4'-nitrobiphenyl

HRID 34689

반응식

HRID 34689 반응식
C(O)C.[OH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1.[OH-].[K+].Br[CH2:23][CH2:24][CH2:25][CH:26]=[CH2:27]>O>[CH2:27]([O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)=[CH:9][CH:10]=1)[CH2:26][CH2:25][CH:24]=[CH2:23]

참가 물질

6

반응물 4

HCID 702EthanolHCID 14797Potassium HydroxideHCID 707041-Pentene, 5-bromo-HCID 1380784-Hydroxy-4'-nitrobiphenyl

생성물 1

HCID 199012844-(4-Pentenoxy)-4'-nitrobiphenyl

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 400 ml ethanol is added 21.5 g of 4-hydroxy-4'-nitrobiphenyl, and the mixture heated to reflux. A solution of 7.1 g KOH in 30 ml of water is added dropwise at reflux temperatures. After complete addition, 18 g of 5-bromo-1-pentene is added and the reaction medium is heated at reflux temperature for about 15 hours. Ethanol is removed under vacuum from the cooled mixture, and the solid residue is slurried with water in a blender, filtered, washed with water, and air dried. The product then is recrystallized from 90/10 hexane/toluene, mp 74°-76° C.

후처리

  1. temperaturethe mixture heated to reflux
  2. temperatureat reflux temperatures
  3. additionis added
  4. temperaturethe reaction medium is heated
  5. temperatureat reflux temperature for about 15 hours
  6. customEthanol is removed under vacuum from the cooled mixture
  7. filtrationfiltered
  8. washwashed with water, and air
  9. customdried
  10. customThe product then is recrystallized from 90/10 hexane/toluene, mp 74°-76° C.

출처 및 근거

ORD 기록
ord-58fe152fc2844904a472c431c60d2ea8
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762912

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