Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methylcyclopropane-1-sulfonamide → HCID 68748369, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methylcyclopropane-1-sulfonamide | HCID 21889814 | — |
| 반응물 | 14-Tert-butoxycarbonylamino-18-(isoquinolin-1-yloxy)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]-nonadec-7-ene-4-carboxylic acid | HCID 72427434 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | HCID 68748369 | HCID 68748369 | 58.1% |
반응 단계
Prepared from 14-tert-butoxycarbonylamino-18-(isoquinolin-1-yloxy)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]-nonadec-7-ene-4-carboxylic acid etherate (105 mg, 0.177 mmol) and 1-methyl-cyclopropanesulfonic acid amide (31 mg, 0.23 mmol, prepared as described above). Flash chromatography (2% methanol/methylene chloride) gave 73 mg (58%) of [18-(isoquinolin-1-yloxy)-4-(1-methyl-cyclopropanesulfonylaminocarbonyl)-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.04,6]nonadec-7-en-14-yl]-carbamic acid tert-butyl ester as a white powder: LC-MS (Method A, retention time: 3.50 min), MS m/z 710 (M++1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07173004B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-db9b0744513e4e4799610ef81c5aa6b8 |
| 출처 메모 | uspto-grants-2007_02 |