Nitric Acid → 4-(Benzyloxy)-2-nitrophenol

HRID 34701

반응식

HRID 34701 반응식
[N+:1]([O-:4])(O)=[O:2].[CH2:5]([O:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(OC(=O)C)C>[N+:1]([C:15]1[CH:14]=[C:13]([O:12][CH2:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:18]=[CH:17][C:16]=1[OH:19])([O-:4])=[O:2]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 7638Monobenzone

생성물 1

HCID 46066344-(Benzyloxy)-2-nitrophenol수율 37%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Fumic nitric acid (d=1.52, 43.6 g, 0.70 mole) was dropwise added under stirring to 4-benzyloxyphenol (138.0 g, 0.69 mole) in ethylacetate (500 ml) at 0° C. The resulting solution was raised at room temperature and then washed in separatory funnel with sodium hydrogen carbonate in water (saturated solution). The organic layer was separated and evaporated under vacuum and the residual solid was crystallized from methanol (100 ml) to give nitrophenol (Yield of (a): 62.54 g, 36%) as yellow prisms. The product structure was confirmed by NMR and IR spectra.

후처리

  1. washwashed in separatory funnel with sodium hydrogen carbonate in water (saturated solution)
  2. customThe organic layer was separated
  3. customevaporated under vacuum
  4. customthe residual solid was crystallized from methanol (100 ml)

출처 및 근거

ORD 기록
ord-7835854324c54d07bcfc2e65b3493c6e
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762925

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