Piperidine → HCID 22314140, 화합물

반응식

Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:25]=[CH:24][C:10]2[C:11]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)=[N:12][S:13][C:9]=2[CH:8]=1.[NH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[N:26]1([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:25]=[CH:24][C:10]3[C:11]([C:14]4[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=4)=[N:12][S:13][C:9]=3[CH:8]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

참가 물질

반응물 2

HCID 8082Piperidine

HCID 22314024HCID 22314024, 화합물

생성물 1

HCID 22314140HCID 22314140, 화합물

실험 절차

According to the method in example 7, 6-(4-Bromo-butoxy)-3-(4-trifluoromethyl-phenyl)-benzo[d]isothiazole and Piperidine were converted to yield 6-(4-Piperidin-1-yl-butoxy)-3-(4-trifluoromethyl-phenyl)-benzo[d]isothiazole, MS: 435 (MH+).

출처 및 근거

ORD 기록: ord-ef1ff86e7b49467db2420db99e57b5a9
출처 데이터셋: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07173043B2

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