Hydrochloric Acid → 4-[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-2-furaldehyde

HRID 347316

반응식

HRID 347316 반응식
[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]3[CH:16]=[C:17]([CH:20]4OCC[O:21]4)[O:18][CH:19]=3)[CH:5]=[CH:4][C:3]1=2.Cl>C1COCC1>[CH3:1][C:2]1([CH3:25])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]3[CH:16]=[C:17]([CH:20]=[O:21])[O:18][CH:19]=3)[CH:5]=[CH:4][C:3]1=2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21082601HCID 21082601, 화합물

생성물 1

HCID 210826444-[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl]-2-furaldehyde

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A round bottom flask was mixed with 2-{4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro- 2-naphthalenyl)methyl]-2-furyl}-1,3-dioxolane (246 mg, 0.72 mmol), 3.0 N HCl (10 mL) and THF (20 mL). The reaction mixture stirred for 16 hours at room temperature and was concentrated to one half volume. The resulting mixture was partitioned between saturated NaCl and ether. The ether layer was dried over MgSO4 and concentrated to dryness. The resulting oil showed an inseparable impurity by TLC and the product was used without further purification.

후처리

  1. concentrationwas concentrated to one half volume
  2. customThe resulting mixture was partitioned between saturated NaCl and ether
  3. dry with materialThe ether layer was dried over MgSO4
  4. concentrationconcentrated to dryness
  5. customthe product was used without further purification

출처 및 근거

ORD 기록
ord-bce71868654642e69db07a6b4dc933fd
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07173134B2

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