Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-acetyl-N,N-dimethylbenzene-1-sulfonamide → HCID 11202657, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-acetyl-N,N-dimethylbenzene-1-sulfonamide | HCID 2064041 | — |
| 반응물 | 5-(1H-indol-2-yl)-2,4-dimethoxybenzaldehyde | HCID 16115621 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | HCID 11202657 | HCID 11202657 | 12% |
반응 단계
The title compound was prepared in an analogous manner as Ex-1 using 5-(1H-indol-2-yl)-2,4-dimethoxybenzaldehye (Ex-32B) and 4-acetyl-N,N-dimethylbenzenesulfonamide (Ex-31A), 12% yield after silica gel column chromatography (hexane/EtOAc, 2:1), yellow solid, mp 158–162° C. 1H-NMR (300 MHz, CDCl3) δ 9.39 (br, 1H), 8.15 (m, 2H), 8.08 (d, J=9 Hz, 2H), 7.91 (d, J=9Hz, 2H), 7.64 (d, J=7 Hz, 1H), 7.57 (d, J=15 Hz, 1H), 7.42 (d, J=8 Hz, 1H), 7.09–7.21 (m, 2H), 6.87 (d, J=2Hz, 1H), 6.60 (s, 1H), 4.10 (s, 3H), 4.01 (s, 3H), 2.76 (s, 6H). HRMS (ESI) Calcd. for C27H26N2O5S: 491.1641 (M+H)+; Found: 491.1638.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07173129B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-825b3bb5db184259822a1ab95981f0cd |
| 출처 메모 | uspto-grants-2007_02 |