4-acetyl-N,N-dimethylbenzene-1-sulfonamide → HCID 11202657, 화합물

HRID 347351

반응식

HRID 347351 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[C:11]([O:20][CH3:21])=[CH:12][C:13]([O:18][CH3:19])=[C:14]([CH:17]=1)[CH:15]=O.[C:22]([C:25]1[CH:30]=[CH:29][C:28]([S:31]([N:34]([CH3:36])[CH3:35])(=[O:33])=[O:32])=[CH:27][CH:26]=1)(=[O:24])[CH3:23]>CCCCCC.CCOC(C)=O>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[C:11]([O:20][CH3:21])=[CH:12][C:13]([O:18][CH3:19])=[C:14](/[CH:15]=[CH:23]/[C:22]([C:25]2[CH:26]=[CH:27][C:28]([S:31]([N:34]([CH3:35])[CH3:36])(=[O:33])=[O:32])=[CH:29][CH:30]=2)=[O:24])[CH:17]=1

참가 물질

4

반응물 2

HCID 20640414-acetyl-N,N-dimethylbenzene-1-sulfonamideHCID 161156215-(1H-indol-2-yl)-2,4-dimethoxybenzaldehyde

생성물 1

HCID 11202657HCID 11202657, 화합물수율 12%

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

The title compound was prepared in an analogous manner as Ex-1 using 5-(1H-indol-2-yl)-2,4-dimethoxybenzaldehye (Ex-32B) and 4-acetyl-N,N-dimethylbenzenesulfonamide (Ex-31A), 12% yield after silica gel column chromatography (hexane/EtOAc, 2:1), yellow solid, mp 158–162° C. 1H-NMR (300 MHz, CDCl3) δ 9.39 (br, 1H), 8.15 (m, 2H), 8.08 (d, J=9 Hz, 2H), 7.91 (d, J=9Hz, 2H), 7.64 (d, J=7 Hz, 1H), 7.57 (d, J=15 Hz, 1H), 7.42 (d, J=8 Hz, 1H), 7.09–7.21 (m, 2H), 6.87 (d, J=2Hz, 1H), 6.60 (s, 1H), 4.10 (s, 3H), 4.01 (s, 3H), 2.76 (s, 6H). HRMS (ESI) Calcd. for C27H26N2O5S: 491.1641 (M+H)+; Found: 491.1638.

출처 및 근거

ORD 기록
ord-825b3bb5db184259822a1ab95981f0cd
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07173129B2

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