Water → 1-(4-Bromo-1,3-thiazol-2-YL)piperidine
반응식
[N:1]1([C:7]2[S:8][CH:9]=[C:10]([Sn](C)(C)C)[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:16]C1SC=C(Br)N=1.O>N1CCCCC1>[N:1]1([C:7]2[S:8][CH:9]=[C:10]([Br:16])[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
Synthesis of 2-Piperidinyl(trimethylstannyl)thiazole 373 as illustrated in FIG. 53. 2,4-Dibromothiazole (358; 1.0 equiv) was dissolved in piperidine (0.5 M) and the reaction was warmed to 50° C. for 8 h, upon which completion of the reaction was indicated by TLC. The mixture was poured into water and extracted with ether (2×). Drying (MgSO4) and evaporation of the solvents gave 2-piperidinyl-4-bromothiazole 372, which was isolated after flash column chromatography (silica gel, 5% EtOAc in hexanes) in 100% yield.
후처리
- extractionextracted with ether (2×)
- customDrying
- custom(MgSO4) and evaporation of the solvents
출처 및 근거
- ORD 기록
- ord-63123ab641a34326bbff78639f93cc89
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07173137B2
반응 노트
불러오는 중…