Tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)but-2-enoate → Tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)butyrate

HRID 347417노트

반응식

HRID 347417 반응식
[CH2:1]([C:3](=[CH:11][CH2:12][C@H:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]([OH:19])[CH2:14]1)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[CH3:2]>CO>[CH2:1]([CH:3]([CH2:11][CH2:12][C@H:13]1[CH2:18][CH2:17][CH2:16][C@@H:15]([OH:19])[CH2:14]1)[C:4]([O:6][C:7]([CH3:10])([CH3:8])[CH3:9])=[O:5])[CH3:2]

참가 물질

3

반응물 1

HCID 69494094Tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)but-2-enoate

생성물 1

HCID 69494197Tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)butyrate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.65 g of tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)but-2-enoate are dissolved in 50 ml of methanol, and 100 mg of Perlmans catalyst are added. The mixture is stirred under an atmosphere of hydrogen for 24 hours. The catalyst is filtered off through Celite, and the filtrate is then concentrated under reduced pressure. This gives 1.49 g of tert-butyl 2-ethyl-4-(cis-3-hydroxycyclohexyl)butyrate as a colorless oil. C16H30O3 (270.40), Rf(n-heptane:ethyl acetate=5:1)=0.10.

후처리

  1. addition100 mg of Perlmans catalyst are added
  2. filtrationThe catalyst is filtered off through Celite
  3. concentrationthe filtrate is then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7d160a2e317b4bd79e0bfc927ce8188c
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07173151B2

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