Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methylthio-1-methylamino-2-nitroethylene → 1-(2-[4-(2-[2,2,2-Trifluoroethyl]guanidino)pyrimid-2-yl-methylthio]ethylamino)-1-methylamino-2-nitroethylene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methylthio-1-methylamino-2-nitroethylene | HCID 123549 | — |
| 반응물 | 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(2-aminoethyl)thiomethylpyrimidine | HCID 21298720 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(2-[4-(2-[2,2,2-Trifluoroethyl]guanidino)pyrimid-2-yl-methylthio]ethylamino)-1-methylamino-2-nitroethylene | HCID 70418646 | 63.3% |
반응 단계
A mixture of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[(2-aminoethyl)thiomethyl]pyrimidine (0.31 g.) 1-methylamino-1-methylthio-2-nitroethylene (0.15 g.) and acetonitrile (5 ml.) was heated under reflux for 6 hours and then left at room temperature for 18 hours. The yellow crystalline precipitate was collected to give 1-(2-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-ylmethylthio]ethylamino)-1-methylamino-2-nitroethylene (0.26 g.), m.p. 154°-157° after recrystallisation from ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762932 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-ed279f94630a4ea5b86684ffc48f68de |
| 출처 메모 | uspto-grants-1988_08 |