Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(4-Bromobutyl)phthalimide → 4-Amino-2-(4-phthalimidobutylthio)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(4-Bromobutyl)phthalimide | HCID 93575 | — |
| 반응물 | 1,5-Diazabicyclo(5,4,0)undec-5-ene | HCID 314112 | — |
| 반응물 | HCID 178507915 | HCID 178507915 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Amino-2-(4-phthalimidobutylthio)pyrimidine | HCID 21298754 | 86.7% |
반응 단계
A mixture of 2-thiocytosine (0.25 g.), 1,5-diazabicyclo[5,4,0]undec-5-ene (0.33 g.), ethanol (10 ml.) and N-(4-bromobutyl)phthalimide (0.62 g.) was stirred at room temperature for 18 hours and then evaporated to dryness. The residue was partitioned between water and ethyl acetate and the ethyl acetate phase was dried and evaporated to dryness. The residue was recrystallised from acetonitrile to give 4-amino-2-(4-phthalimidobutylthio)pyrimidine (0.56 g.), m.p. 164°-167°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762932 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-a682a20e344347838a09dbb729f50832 |
| 출처 메모 | uspto-grants-1988_08 |