3-Hydroxybenzaldehyde → 2-Chloro-3-hydroxybenzaldehyde
반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].C(O[Cl:15])(C)(C)C>CC(O)=O>[Cl:15][C:3]1[C:2]([OH:1])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[O:6]참가 물질
4
실험 절차
To a suspension of 3-hydroxybenzaldehyde (20.12 g, 160 mmol) in HOAc (40 mL) was added carefully tBuOCl (20 mL, 176 mmol) with stirring. The reaction became a clear solution and strongly exothermic. It was allowed to cool and stirred for 16 hours, resulting in a white precipitate. The solid was filtered, washed with H2O and dried to give 2-chloro-3-hydroxybenzaldehyde (13.77 g, 55% ), GCMS (El) m/z 156, 158 (M+).
후처리
- temperatureto cool
- stirringstirred for 16 hours
- customresulting in a white precipitate
- filtrationThe solid was filtered
- washwashed with H2O
- customdried
출처 및 근거
- ORD 기록
- ord-af753c20d3334f6db41d0a87250830dc
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07176211B2
반응 노트
불러오는 중…