Nitronium tetrafluoroborate → HCID 21084113, 화합물
반응식
[Br:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[CH:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.F[B-](F)(F)F.[O:17]=[N+:18]=[O:19]>C(#N)C>[Br:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[C:10]([N+:18]([O-:19])=[O:17])=[C:6]2[CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a solution of 7-bromo-2-methylpyrazolo[1,5-a]pyridine (1.3 g) dissolved in acetonitrile (25 mL) was added nitronium tetrafluoroborate (900 mg) while stirring on ice, and the reaction mixture was stirred for 10 minutes. The obtained reaction mixture was added to ice water, and the precipitated crystals were collected by filtration, washed with water and then dried under reduced pressure to afford crude crystals. These were purified by silica gel column chromatography and the title compound (900 mg) was obtained as yellow crystals from the n-hexane:ethyl acetate (5:1) fraction.
후처리
- stirringthe reaction mixture was stirred for 10 minutes
- customThe obtained reaction mixture
- filtrationthe precipitated crystals were collected by filtration
- washwashed with water
- customdried under reduced pressure
- customto afford crude crystals
- customThese were purified by silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-8f258cb84bf54e54b7f4f4715806f635
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07176216B2
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