Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → 4-Amino-2-(2-phthalimidoethylthio)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- | HCID 11325 | — |
| 반응물 | 1,2,3,4,6,7,8,10A-octahydropyrimido[1,2-a]azepine | HCID 15072656 | — |
| 반응물 | HCID 178507915 | HCID 178507915 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Amino-2-(2-phthalimidoethylthio)pyrimidine | HCID 21298737 | — |
반응 단계
A mixture of 2-thiocytosine (0.51 g.), dimethylformamide (5 ml.), N-(2-bromoethyl)phthalimide (1.12 g.) and 1,8-diazabicyclo[5,4,0]undec-5-ene (0.67 g.) was stirred at room temperature for 6 hours and then evaporated to dryness. The residue was stirred with a mixture of water and ethyl acetate and the insoluble material collected to give 4-amino-2-(2-phthalimidoethylthio)pyrimidine which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762932 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-8ce077abc7b747369a5f93591d8d0d13 |
| 출처 메모 | uspto-grants-1988_08 |