Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-(3,5-Difluoropyridin-2-yl)methanamine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Cyano-3,5-difluoropyridine | HCID 2783253 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 생성물 | 1-(3,5-Difluoropyridin-2-yl)methanamine hydrochloride | HCID 21069853 | 100% |
반응 단계
A mixture of 3,5-difluoropicolinonitrile (1.4 g, 10 mmol), conc. HCl (12 ml) and 10% Pd—C (200 mg) in 1:1 ethanol/tetrahydrofuran was shaken under a hydrogen atmosphere (50 psi) for 5 h. The reaction mixture was filtered and the ethanol removed in vacuo. The remaining solution was lyophilized to afford an off-white solid (2.16 g, 100% yield). LCMS (M+H) calcd for C6H7F2N2: 145.06; found: 145.12.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07176196B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-413d93ee44f64b02b3b6a4237fc7b668 |
| 출처 메모 | uspto-grants-2007_02 |