Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Aminobenzyl alcohol → 1-(3-Hydroxymethylphenyl)-3-(2,2,2-trifluoroethyl)thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Aminobenzyl alcohol | HCID 80293 | — |
| 반응물 | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 1-(3-Hydroxymethylphenyl)-3-(2,2,2-trifluoroethyl)thiourea | HCID 21298721 | — |
반응 단계
m-Aminobenzyl alcohol (0.123 g.) and 2,2,2-trifluoroethylisothiocyanate (0.141 g.) were heated under reflux in acetone (5 ml.) for 2 hours. Volatile material was evaporated in vacuo and the crude residue was fractionated on a silica gel column (20 cm.×1 cm. diameter) eluted with ethyl acetate to give 1-(3-hydroxymethylphenyl)-3-(2,2,2-trifluoroethyl)thiourea. The n.m.r. spectrum in CDCl3 using tetramethylsilane as internal standard (δ=0) had the following resonances (δ): 7.2 (4H, multiplet); 4.6 (2H, singlet); 4.3 (2H, multiplet).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04762932 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-a8255db0fab5427fa49e131da1c87698 |
| 출처 메모 | uspto-grants-1988_08 |