3,4-Difluorophenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester → 2-(3,4-Difluorophenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester

HRID 348355노트

반응식

HRID 348355 반응식
[CH2:1]([O:3][C:4](=[O:31])[C:5]([O:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[C:25]([F:30])[CH:24]=1)([CH3:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:31])[C:5]([O:22][C:23]1[CH:28]=[CH:27][C:26]([F:29])=[C:25]([F:30])[CH:24]=1)([CH3:21])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 693538473,4-Difluorophenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester

생성물 1

HCID 693198392-(3,4-Difluorophenoxy)-3-(4-hydroxyphenyl)-2-methyl-propionic acid ethyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

2-(3,4-Difluorophenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic acid ethyl ester (2.1 mmol) was dissolved in ethyl acetate (30 mL) and treated with 5% palladium on carbon (300 mg), and stirred under an atmosphere of hydrogen for 20 h. The suspension was filtered through celite and concentrated in vacuo to an oil.

후처리

  1. filtrationThe suspension was filtered through celite and
  2. concentrationconcentrated in vacuo to an oil

출처 및 근거

ORD 기록
ord-28e7ac0300e04b638acd41ab08e6faa1
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176224B2

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