Triethylamine → (2R)-Butan-2-YL methanesulfonate

HRID 348419

반응식

HRID 348419 반응식
[CH3:1][S:2]([O:5]S(C)(=O)=O)(=[O:4])=[O:3].[CH3:10][C@@H:11](O)[CH2:12][CH3:13].C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:5][C@H:11]([CH3:10])[CH2:12][CH3:13])(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 81560Methanesulfonic anhydrideHCID 84682(-)-2-Butanol

생성물 1

HCID 148500(2R)-Butan-2-YL methanesulfonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of methanesulphonic anhydride (8.33 g, 47.8 mmol) in dichloromethane (30 ml) was added dropwise over 30 minutes to an ice-cooled solution of (R)-2-butanol (4.0 ml, 43.5 mmol) and triethylamine (6.65 ml, 47.8 mmol) in dichloromethane (70 ml). The reaction was then allowed to warm to room temperature and stirred for 18 hours. The mixture was then washed with water, 2N hydrochloric acid, then dried (Na2SO4) and evaporated under reduced pressure to give the title compound as a pale yellow oil, 7.0 g.

후처리

  1. washThe mixture was then washed with water, 2N hydrochloric acid
  2. dry with materialdried (Na2SO4)
  3. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-90301e4243ad4986aac61da05fd1e19a
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176311B2

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