Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-3-ol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(2,5-Dimethyl-1H-pyrrol-1-yl)pyridin-3-ol | HCID 2774691 | — |
| 반응물 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| 생성물 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-yl ester | HCID 69523459 | 28% |
반응 단계
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 2-(2,5-dimethylpyrrol-1-yl)pyridin-3-ol (32 mg, 0.17 mmol) as the source alcohol. Chromatographic (30–40% ethyl acetate/hexane) purification yielded 22 mg (28%) of the titled compound. ESI-MS t/z 462 (MH+), 460 (M−H−).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07176310B1 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-6bf752b0309a4bf8a2d5128e0253f2b9 |
| 출처 메모 | uspto-grants-2007_02 |