Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanol → [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-adamantan-1-yl-ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Tricyclo(3.3.1.1'3,7)dec-1-yl)ethanol | HCID 110810 | — |
| 반응물 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid | HCID 21087356 | — |
| 생성물 | [5-(4-Fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid 2-adamantan-1-yl-ethyl ester | HCID 69522587 | 75% |
반응 단계
The titled compound was prepared from [5-(4-fluorophenylcarbamoyl)pyrimidin-2-yloxy]acetic acid using 1-adamantaneethanol (27 mg, 0.15 mmol) as the coupling partner. Concentration (no chromatography) yielded 58 mg (75%) of the titled compound. ESI-MS m/z 454 (MH+), 452 (M−H−).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07176310B1 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-e6c4e900255f4da29ea14e6aeb60ee08 |
| 출처 메모 | uspto-grants-2007_02 |