Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → (1-methyl-1H-benzo[d]imidazol-5-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylate | HCID 965319 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (1-methyl-1H-benzo[d]imidazol-5-yl)methanol | HCID 14518388 | 58.6% |
반응 단계
A solution of methyl 1-methylbenzimidazole-5-carboxylate (1.6 g, 8.42 mmol) in dry THF (80 mL) was treated with LiAlH4 (1.59 g, 42.1 mmol) and the mixture stirred for 2 hours. 1.5 mL of 5% NaOH solution was then added, and the solid which precipitated was filtered through diatomaceous earth. The filtrate was collected and the solvent removed under reduced pressure to give 0.8 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07176322B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-ae711156e21b430f98d5dddcc4818b33 |
| 출처 메모 | uspto-grants-2007_02 |