Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 2-[(4-Chlorophenylthio)methylamino]-4-methoxy-6-methylpyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | p-Chlorothiophenol | HCID 7815 | — |
| 반응물 | 4-Methoxy-6-methylpyrimidin-2-amine | HCID 587236 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-[(4-Chlorophenylthio)methylamino]-4-methoxy-6-methylpyrimidine | HCID 23043234 | — |
반응 단계
A mixture of 13.99 g of 2-amino-4-methoxy-6-methylpyrimidine (0.1 mole), 14.8 g of 4-chlorothiophenol (0.1 mole), 9.4 g of aqueous 35% formaldehyde (0.11 mole) and 1 g of acetic acid are heated under reflux for 1 hour in 100 ml of methanol. The resultant solution is clarified by filtration, diluted with 150 ml of toluene and then the solvent is removed in a rotary evaporator. The residue crystallises after standing for some time. The melting point is 78°-82° after recrystallisation from hexane. The yield is 24 g (81% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764203 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-f56531faf056450bba8134dfded76144 |
| 출처 메모 | uspto-grants-1988_08 |