2-[2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazol-5-ylmethyl]isoindole-1,3-dione → [4-(6-aminomethyl-1-propyl-1H-benzimidazol-2-yl)butyl]dipropylamine

HRID 348757노트

반응식

HRID 348757 반응식
[CH2:1]([N:4]([CH2:33][CH2:34][CH3:35])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:10]([CH2:30][CH2:31][CH3:32])[C:11]2[CH:17]=[C:16]([CH2:18][N:19]3C(=O)C4C(=CC=CC=4)C3=O)[CH:15]=[CH:14][C:12]=2[N:13]=1)[CH2:2][CH3:3]>CN.CO>[NH2:19][CH2:18][C:16]1[CH:15]=[CH:14][C:12]2[N:13]=[C:9]([CH2:8][CH2:7][CH2:6][CH2:5][N:4]([CH2:1][CH2:2][CH3:3])[CH2:33][CH2:34][CH3:35])[N:10]([CH2:30][CH2:31][CH3:32])[C:11]=2[CH:17]=1

참가 물질

3

반응물 1

HCID 231555012-[2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazol-5-ylmethyl]isoindole-1,3-dione

생성물 1

HCID 23079304[4-(6-aminomethyl-1-propyl-1H-benzimidazol-2-yl)butyl]dipropylamine수율 103.5%

시약·촉매·용매 1

HCID 57454252Monomethylamine methanol용매

실험 절차

The compound (173 mg) obtained in Example 125-5 was dissolved in a 40% methylamine/methanol solution (1.8 ml) and stirred at room temperature for 17 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and the residue was then purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (130 mg) as a pale-yellow viscous substance.

후처리

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. customthe residue was then purified through silica gel column chromatography (chloroform/ethyl acetate)

출처 및 근거

ORD 기록
ord-e60939a44bab46ff98692f95e6761446
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176227B2

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