Monomethyl-5-nitroisophthalate → 3-Amino-5-(methoxycarbonyl)benzoic acid

HRID 348787

반응식

HRID 348787 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:14]([O-:16])=[O:15])[CH:7]=[C:8]([CH:13]=1)[C:9]([O:11][CH3:12])=[O:10])([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH:7]=[C:8]([C:9]([O:11][CH3:12])=[O:10])[CH:13]=1)[C:14]([OH:16])=[O:15]

참가 물질

4

반응물 1

HCID 6931682Monomethyl-5-nitroisophthalate

생성물 1

HCID 135576433-Amino-5-(methoxycarbonyl)benzoic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A suspension of mono-methyl 5-nitro-isophthalate (22.5 g, 100 mmol) and palladium on carbon (5%, 2.00 g) in methanol (100 mL) is shaken in a hydrogenation apparatus under hydrogen (50 psi) for 3 hours. The mixture is then filtered through diatomaceous earth and concentrated to give the title compound, NMR (300 MHz, CDCl3) delta 7.67, 7.41, 7.40 and 3.83; MS (ESI—) for C9H9NO4 m/z (M−H)−=194.

후처리

  1. filtrationThe mixture is then filtered through diatomaceous earth
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-23aa14780da64a0580a587d752837938
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176242B2

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