Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butyl iodide → methyl 1-butyl-1H-indole-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butyl iodide | HCID 10962 | — |
| 반응물 | Methyl indole-6-carboxylate | HCID 639844 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | methyl 1-butyl-1H-indole-6-carboxylate | HCID 21086134 | — |
반응 단계
Methyl 1H-indole-6-carboxylate (4.17 g) was dissolved in DMSO (30 mL), and potassium tert-butoxide (2.93 g) was added. The mixture was stirred for ten min at room temperature. Iodobutane (3.0 mL) was added. The mixture was allowed to stir for three additional hours. The mixture was partitioned between ethyl acetate and water and brine, dried over sodium sulfate, filtered, and concentrated to give methyl 1-butyl-1H-indole-6-carboxylate (4.53 g). MS (ESI+) for C14H17NO2+H1 m/z 232.12 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07176242B2 |
| 출처 데이터셋 | uspto-grants-2007_02 |
| ORD ID | ord-ccf495f13d924e488b5095017a02e098 |
| 출처 메모 | uspto-grants-2007_02 |