Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propanoyl bromide, 2-bromo- → 6-(2-Bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propanoyl bromide, 2-bromo- | HCID 79047 | — |
| 반응물 | 3,4-Dihydro-3-methyl-2(1H)-quinazolinone | HCID 3846558 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Carbon Disulfide | HCID 6348 | — |
| 생성물 | 6-(2-Bromopropionyl)-3,4-dihydro-3-methyl-2(1H)-quinazolinone | HCID 13827166 | — |
반응 단계
2-Bromopropionyl bromide (71.02 g) is added dropwise to a stirred mixture of 3,4-dihydro-3-methyl-2(1H)quinazolinone (26.75 g) and anhydrous aluminum chloride (54.98 g) in carbon disulfide (350 ml). The reaction mixture is stirred under reflux for 5 hrs., the carbon disulfide decanted, and the residue treated with HCl (6N). The resulting solid is filtered, and washed with water and dried in vacuo to obtain 6-(2-bromopropionyl)-3,4,dihydro-3-methyl-2(1H)-quinazolinone which is used in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764512 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-b3ac7eeee5c14cba98b5023f718d0974 |
| 출처 메모 | uspto-grants-1988_08 |