Methanol → Methyl 1-butylisoquinoline-7-carboxylate

HRID 349058노트

반응식

HRID 349058 반응식
[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([OH:17])=[O:16])[CH:13]=2)[CH:8]=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4].S(=O)(=O)(O)O.[CH3:23]O>>[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17][CH3:23])=[O:16])[CH:13]=2)[CH:8]=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 210851771-Butylisoquinoline-7-carboxylic acid

생성물 1

HCID 21086138Methyl 1-butylisoquinoline-7-carboxylate

실험 절차

A solution of 1-butylisoquinoline-7-carboxylic acid (325 mg, 1.41 mmol) in methanol (25 mL) containing concentrated sulfuric acid (800 μL) was refluxed overnight. The reaction mixture was then concentrated under reduced pressure, diluted with methylene chloride, washed with water, and saturated sodium chloride. The organic layer was then dried (sodium sulfate), filtered, and concentrated to yield methyl 1-butylisoquinoline-7-carboxylate (350 mg): ESI MS m/z 244 [M+H]+;

후처리

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was then concentrated under reduced pressure
  3. additiondiluted with methylene chloride
  4. washwashed with water, and saturated sodium chloride
  5. dry with materialThe organic layer was then dried (sodium sulfate)
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bf3650519a0643269c5d016c44e4dd2a
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176242B2

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