Thionyl Chloride → 4-Oxo-3-thiazolidinylacetyl chloride

HRID 34907노트

반응식

HRID 34907 반응식
S(Cl)([Cl:3])=O.[O:5]=[C:6]1[CH2:10][S:9][CH2:8][N:7]1[CH2:11][C:12]([OH:14])=O>ClCCl.O1CCCC1>[O:5]=[C:6]1[CH2:10][S:9][CH2:8][N:7]1[CH2:11][C:12]([Cl:3])=[O:14]

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 51472572-(4-Oxo-1,3-thiazolidin-3-yl)acetic acid

생성물 1

HCID 212972254-Oxo-3-thiazolidinylacetyl chloride

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

Thionyl chloride (2.00 ml) was added dropwise to a solution of 4-oxo-3-thiazolidinylacetic acid (1.60 g) in a mixture of dichloromethane (20 ml) and tetrahydrofuran (5.0 ml) at room temperature. After the mixture was stirred for 5 hours at the same temperature, the solvent was evaporated in vacuo to give 4-oxo-3-thiazolidinylacetyl chloride (1.78 g) as brown semisolid.

후처리

  1. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-566cc7d4e2bc48d4b9bbc4f953cfff39
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764514

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