Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Dimethylaniline → N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Dimethylaniline | HCID 6896 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 2-(4-Oxo-3-thiazolidinyl)propionic acid | HCID 23245350 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide | HCID 13853984 | 45.7% |
반응 단계
A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764514 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-6a9aab5ee7f74d7c9c9deececbc2446a |
| 출처 메모 | uspto-grants-1988_08 |