2-Cyclohexen-1-one → 1,3-Diethyl 2-(3-oxocyclohexyl)propanedioate

반응식

C1(=O)CCCC=C1.[CH2:8]([O:10][C:11](=[O:28])[CH:12]([CH:18]1[CH2:23][CH2:22][CH:21](CCC)[C:20](=[O:27])[CH2:19]1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH3:9]>>[CH2:16]([O:15][C:13](=[O:14])[CH:12]([CH:18]1[CH2:23][CH2:22][CH2:21][C:20](=[O:27])[CH2:19]1)[C:11]([O:10][CH2:8][CH3:9])=[O:28])[CH3:17]

참가 물질

반응물 2

HCID 135942-Cyclohexen-1-one

HCID 574874362-(3-Oxo-4-propylcyclohexyl)-malonic acid diethyl ester

생성물 1

HCID 3170491,3-Diethyl 2-(3-oxocyclohexyl)propanedioate수율 88%

실험 절차

Step 1 (3-Oxo-cyclohexyl)-malonic acid diethyl ester was prepared in 88% yield from cyclohexenone by the method described above for the synthesis of 2-(3-oxo-4-propyl-cyclohexyl)-malonic acid diethyl ester: 1H NMR (300 MHz, CDCl3) δ 4.44–4.12 (m, 4H), 2.88–1.22 (m, 16H).

출처 및 근거

ORD 기록: ord-051d527bec824cc8a072ae0b5466a09d
출처 데이터셋: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07176242B2

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