Potassium Carbonate → 2-Bromo-3-(but-2-ynyl)-5-(4-methyl-quinazolin-2-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

HRID 349195노트

반응식

HRID 349195 반응식
[Br:1][C:2]1[N:3]([CH2:12][C:13]#[C:14][CH3:15])[C:4]2[C:9](=[O:10])[NH:8][N:7]=[CH:6][C:5]=2[N:11]=1.Cl[CH2:17][C:18]1[N:27]=[C:26]([CH3:28])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[N:3]([CH2:12][C:13]#[C:14][CH3:15])[C:4]2[C:9](=[O:10])[N:8]([CH2:17][C:18]3[N:27]=[C:26]([CH3:28])[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[N:19]=3)[N:7]=[CH:6][C:5]=2[N:11]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 2415182-(Chloromethyl)-4-methylquinazolineHCID 219476582-Bromo-3-(but-2-ynyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

생성물 1

HCID 160377782-Bromo-3-(but-2-ynyl)-5-(4-methyl-quinazolin-2-ylmethyl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 365 mg 2-bromo-3-(2-butyn-1-yl)-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one, 265 mg 2-chloromethyl-4-methyl-quinazoline and 210 mg potassium carbonate in 6 ml acetonitrile is stirred for 17 h at ambient temperature. Then the reaction mixture is filtered through 5 g aluminium oxide with ethyl acetate and the filtrate is evaporated down. The residue is triturated in diisopropylether, separated from the ether and dried.

후처리

  1. filtrationThen the reaction mixture is filtered through 5 g aluminium oxide with ethyl acetate
  2. customthe filtrate is evaporated down
  3. customThe residue is triturated in diisopropylether
  4. customseparated from the ether
  5. customdried

출처 및 근거

ORD 기록
ord-51daa01fe3544f5793140f82110feece
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179809B2

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