2-Chloro-5-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrimidine → 2-Chloro-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrimidine

HRID 349233노트

반응식

HRID 349233 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[N:13]2)=[CH:4][N:3]=1>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[N:13]2)=[CH:4][N:3]=1

참가 물질

4

반응물 1

HCID 860740652-Chloro-5-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrimidine

생성물 1

HCID 860740662-Chloro-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrimidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

2-Chloro-5-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrimidine (2.52 g, 10.8 mmol) is dissolved in ethyl acetate (210 ml) and hydrogenated for 2.5 h at r.t. in the presence of palladium on calcium carbonate (10%, 2.55 g). The reaction mixture is filtered and concentrated in vacuo to yield 2-chloro-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrimidine as a colorless solid. Yield 2.15 g (84%)

후처리

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e8d62ce74d1a4fe5b00240188bfcef13
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179812B2

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