(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acid → Ethyl(2s)-2-[(4s)-4-methyl-2-oxido-5-oxo-1,2,3-oxathiazolidin-3-yl]-pentanoate

HRID 349411노트

반응식

HRID 349411 반응식
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([OH:15])=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].N1([S:21](Cl)=[O:22])C=CN=C1>ClCCl>[CH3:12][C@H:11]1[C:13](=[O:15])[O:14][S:21](=[O:22])[N:10]1[C@@H:4]([CH2:3][CH2:2][CH3:1])[C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

4

반응물 2

HCID 10015159(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoic acidHCID 113325591H-Imidazole-1-sulfinyl chloride

생성물 1

HCID 11242493Ethyl(2s)-2-[(4s)-4-methyl-2-oxido-5-oxo-1,2,3-oxathiazolidin-3-yl]-pentanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Introduce into a reactor 200 g of N-[(S)-ethoxycarbonyl-1-butyl]-(S)-alanine and 1.5 liters of dichloromethane and then, at 0° C., add 325 g of 1H-imidazole-1-sulphinyl chloride. Subsequently, bring the reaction mixture to ambient temperature and then, after stirring for 1 hour, filter off the precipitate formed. The filtrate obtained is evaporated to dryness to yield the expected product in the form of an oil.

후처리

  1. customto ambient temperature
  2. filtrationfilter off the precipitate
  3. customformed
  4. customThe filtrate obtained
  5. customis evaporated to dryness

출처 및 근거

ORD 기록
ord-8480382943764e6d9946aa05c1ece591
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179833B2

반응 노트

불러오는 중…