Cesium carbonate → {4-[5-(3-Bromophenyl) tetrazol-2-ylmethyl]benzyl}phosphonic acid dimethyl ester

HRID 349455

반응식

HRID 349455 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[N:10][NH:11][N:12]=2)[CH:5]=[CH:6][CH:7]=1.[C:13](=O)([O-])[O-].[Cs+].[Cs+].[CH3:19][O:20][P:21]([CH:25](C)[C:26]1[CH:31]=[CH:30][C:29](Br)=[CH:28][CH:27]=1)(=[O:24])[O:22][CH3:23]>CN(C=O)C.C(OCC)(=O)C>[CH3:23][O:22][P:21]([CH2:25][C:26]1[CH:27]=[CH:28][C:29]([CH2:13][N:10]2[N:11]=[N:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=3)=[N:9]2)=[CH:30][CH:31]=1)(=[O:24])[O:20][CH3:19]

참가 물질

6

반응물 3

HCID 10796Cesium carbonateHCID 40730565-(3-bromophenyl)-1H-1,2,3,4-tetrazoleHCID 86626606HCID 86626606, 화합물

생성물 1

HCID 86626605{4-[5-(3-Bromophenyl) tetrazol-2-ylmethyl]benzyl}phosphonic acid dimethyl ester

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 5-(3-bromophenyl)-2H-tetrazole (0.5 g, 2.22 mmol) in DMF (15 mL) was added cesium carbonate (0.94 g, 2.89) and the mixture stirred at room temperature for 15 minutes. To this was added (4-bromo-methylbenzyl) phosphonic acid dimethyl ester (0.85 g, 3.05 mmol) and the reaction mixture stirred over night at room temperature. The reaction mixture was diluted with ethyl acetate, washed with water, brine, dried over MgSO4, filtered, and the evaporated to dryness.

후처리

  1. stirringthe reaction mixture stirred over night at room temperature
  2. washwashed with water, brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe evaporated to dryness

출처 및 근거

ORD 기록
ord-c479c7576f7a455e905f468b16856b1b
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179822B2

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