5-(3-bromophenyl)-1H-1,2,3,4-tetrazole → {4-[5-(3-Bromophenyl)tetrazol-2-ylmethyl]phenoxy}acetic acid tert-butyl ester

HRID 349457

반응식

HRID 349457 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[N:10][NH:11][N:12]=2)[CH:5]=[CH:6][CH:7]=1.[C:13]([O:17][C:18](=[O:29])[CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27]Br)=[CH:23][CH:22]=1)([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18](=[O:29])[CH2:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][N:10]2[N:11]=[N:12][C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=3)=[N:9]2)=[CH:23][CH:22]=1)([CH3:16])([CH3:15])[CH3:14]

참가 물질

3

반응물 2

HCID 40730565-(3-bromophenyl)-1H-1,2,3,4-tetrazoleHCID 68980125(4-Bromomethylphenoxy)acetic acid tert-butyl ester

생성물 1

HCID 68979257{4-[5-(3-Bromophenyl)tetrazol-2-ylmethyl]phenoxy}acetic acid tert-butyl ester수율 84.6%

실험 절차

This reaction was carried out as described in Example D2, Step (a) using 5-(3-bromophenyl)-2H-tetrazole (0.87 g, 2.89 mmol) and (4-bromomethylphenoxy) acetic acid tert-butyl ester (0.50 g, 2.22 mmol) in place of (4-bromo-methylbenzyl) phosphonic acid dimethyl ester. This afforded 0.85 g of light oil (84.6% yield) NMR (CDCl3); 8.28 (s, 1H), 8.07–8.05 (d, 1H), 7.58–7.55 (d, 1H), 7.38–7.31 (m, 3H), 6.90–6.88 (d, 2H), 5.72 (s, 2H), 4.50 (s, 2H), 1.48 (s, 9H)

출처 및 근거

ORD 기록
ord-fda936c9c3ba4f35b4196cc412863974
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179822B2

연결된 노트

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