N-(2-aminoethyl)acetamide → N-{2-[(5-bromofuran-2-yl)formamido]ethyl}acetamide

HRID 34946

반응식

HRID 34946 반응식
[Br:1][C:2]1[O:6][C:5]([C:7](Cl)=[O:8])=[CH:4][CH:3]=1.[C:10]([NH:13][CH2:14][CH2:15][NH2:16])(=[O:12])[CH3:11]>C(Cl)Cl.C(N(CC)CC)C>[NH:13]([CH2:14][CH2:15][NH:16][C:7]([C:5]1[O:6][C:2]([Br:1])=[CH:3][CH:4]=1)=[O:8])[C:10]([CH3:11])=[O:12]

참가 물질

5

반응물 2

HCID 66082N-(2-aminoethyl)acetamideHCID 27570115-Bromofuran-2-carbonyl chloride

생성물 1

HCID 13800218N-{2-[(5-bromofuran-2-yl)formamido]ethyl}acetamide

시약·촉매·용매 2

HCID 6344Dichloromethane용매2회HCID 8471Triethylamine용매

실험 절차

A solution of 22.6 g of 5-bromo-2-furancarboxylic acid chloride in 100 ml of methylene chloride was added dropwise within 20 minutes at 0°-8° to a solution, pre-cooled to 0°, of 11.0 g of monoacetyl-ethylenediamine in 250 ml of methylene chloride and 18 ml of triethylamine. The reaction mixture was stirred at room temperature overnight, suction filtered and washed with methylene chloride. There was obtained N-(2-acetamino ethyl)-5-bromo-2-furancarboxamide as pale beige crystals, m.p. 175°-176°.

후처리

  1. filtrationsuction filtered
  2. washwashed with methylene chloride

출처 및 근거

ORD 기록
ord-06adfa65536a4672ba2c77c29a74e2ea
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764522

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