Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Picolinic acid → Pyridine-2-carbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Picolinic acid | HCID 1018 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 촉매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Pyridine-2-carbonyl chloride | HCID 135034 | — |
반응 단계
10.0% of pyridine-2-carboxylic acid were suspended in 150 ml of toluene and the suspension was heated to reflux for 2 hours with 17.7 ml of thionyl chloride and 3 drops of dimethylformamide. Thereafter, the mixture was evaporated to dryness under reduced pressure, the residue was treated with toluene and again evaporated to dryness. There was obtained picolinic acid chloride as dark green crystals which were used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04764522 |
| 출처 데이터셋 | uspto-grants-1988_08 |
| ORD ID | ord-0c9b8f17431e45df938f2c9f0e1931bb |
| 출처 메모 | uspto-grants-1988_08 |