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Trifluoroacetic acid → (2S)-2-((3S)-3-{(2-Amino-2-oxoethyl)[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoic acid

HRID 349514
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HRID 349514 반응식
[NH2:1][C:2](=[O:34])[CH2:3][N:4]([S:20]([C:23]1[CH:32]=[CH:31][C:30]2[C:25](=[CH:26][CH:27]=[C:28]([Cl:33])[CH:29]=2)[CH:24]=1)(=[O:22])=[O:21])[C@H:5]1[CH2:9][CH2:8][N:7]([C@@H:10]([CH3:18])[C:11]([O:13]C(C)(C)C)=[O:12])[C:6]1=[O:19].FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:1][C:2](=[O:34])[CH2:3][N:4]([S:20]([C:23]1[CH:32]=[CH:31][C:30]2[C:25](=[CH:26][CH:27]=[C:28]([Cl:33])[CH:29]=2)[CH:24]=1)(=[O:22])=[O:21])[C@H:5]1[CH2:9][CH2:8][N:7]([C@@H:10]([CH3:18])[C:11]([OH:13])=[O:12])[C:6]1=[O:19]
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참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69223739tert-Butyl (2S)-2-((3S)-3-{(2-amino-2-oxoethyl)[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoate

생성물 1

HCID 69060748(2S)-2-((3S)-3-{(2-Amino-2-oxoethyl)[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoic acid수율 98.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl (2S)-2-((3S)-3-{(2-amino-2-oxoethyl)[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoate (1.4 g) was dissolved in DCM (35 ml), and trifluoroacetic acid (35 ml) was added. The mixture was stirred at room temperature for 2 h and then evaporated under reduced pressure. The residue was azeotroped with anhydrous dichloromethane and then dried under high vacuum. The residual viscous oil was triturated with diethyl ether to give the title compound (1.23 g) as a white solid.

후처리

  1. customevaporated under reduced pressure
  2. customThe residue was azeotroped with anhydrous dichloromethane
  3. customdried under high vacuum
  4. customThe residual viscous oil was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-0d6eb395d6044eddb89d3fb11022107b
출처 데이터셋
uspto-grants-2007_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07179835B2

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