8alpha-Benzyloxycarbonylamino-6-n-propylergoline → 8alpha-Amino-6-n-propylergoline

HRID 34957노트

반응식

HRID 34957 반응식
C(OC([NH:11][C@H:12]1[CH2:26][C@H:25]2[C@@H:15]([CH2:16][C:17]3[C:27]4[C:20](=[CH:21][CH:22]=[CH:23][C:24]2=4)[NH:19][CH:18]=3)[N:14]([CH2:28][CH2:29][CH3:30])[CH2:13]1)=O)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[NH2:11][C@H:12]1[CH2:26][C@H:25]2[C@@H:15]([CH2:16][C:17]3[C:27]4[C:20](=[CH:21][CH:22]=[CH:23][C:24]2=4)[NH:19][CH:18]=3)[N:14]([CH2:28][CH2:29][CH3:30])[CH2:13]1

참가 물질

5

반응물 2

HCID 139664588alpha-Benzyloxycarbonylamino-6-n-propylergolineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 134688038alpha-Amino-6-n-propylergoline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

12 g (ca 30 mM) of 8α-benzyloxycarbonylamino)-6-n-propylergoline obtained from step (d) and 1.5 g palladium on charcoal (10% by weight) in 500 ml ethanol are hydrogenated at normal pressure until hydrogen uptake ceases. The mixture is filtered and concentrated. This resultant heading compound is crystallised from methanol.

후처리

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated
  3. customis crystallised from methanol

출처 및 근거

ORD 기록
ord-1847d07e81a74fdd8f8adb629f105173
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764517

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